The gameplay of Mutation Madness is a rollercoaster of unpredictability. Players find themselves facing mutated challenges, solving puzzles, and navigating through levels where every corner holds a surprise. The casual aspect ensures accessibility, allowing players to jump in and enjoy the madness without the burden of complex mechanics. Frederico Proenca and Ana Rita Passos, as the developers, showcase their creative flair and independence by collaborating under the PLAYMUTATION banner. The decision to self-publish reinforces their commitment to delivering a game that remains true to their artistic vision, free from the constraints of mainstream gaming.