Slime 3K Rise Against Despot is an adventure game in which you will play the role of a sticky creature seeking to destroy everything in its path. The title is a roguelike, that is, it has randomly generated levels and permadeath, which makes each run unique and challenging. The plot takes place in a post-apocalyptic world where an evil artificial intelligence named D’Spot has seized power. He uses pink goo to grow artificial humans, but one day it becomes self-aware and rebels against him. The monster can devour people, grow weapons from its body, and also use various environmental objects for its own purposes.