DO NOT OPEN is a dynamic puzzle game with horror elements. The main events take place in the United States. There is a mysterious estate in the middle of nowhere in Maryland where a whole group of senior university students who were planning to make a film about the place disappeared one day. Later, in the same region, a mother and daughter disappeared when they got lost in the forest. The main character, a scientist named Michael, came here voluntarily to uncover the secret of these places and save his family. But it soon turns out that perhaps this house belonged to an ancient sorceress, and now some evil entity begins to pursue it.