Anima Flux game takes place in a distant fictional future. People have made impressive progress in the field of technology, which has made it possible to travel across planets, as well as create new, more powerful weapons. The main problem in the galaxy has become bloodthirsty mutants that threaten the civilian population. Not everyone can cope with them, because monsters, in addition to their enormous size, have impressive strength. The main characters are members of a special elite unit, whose task is to destroy mutants. There are two protagonists a man and a woman. In the case of a single playthrough, the player can choose one of them, and in co-op, you can combine heroes.