The plot of the game Corpse Party 2 Dead Patient — unfolds a few months after the events of the previous part. The main character Ayumi Shinozaki paid a very high price for the use of black magic. Despite the events experienced, one cannot count on a peaceful life. Her aunt informs her that the family has kept the mysterious Book of Shadows for generations. In the wrong hands, it can lead to the destruction of the world. At the moment, the tome is located in a former family residence. Ayumi has to find her.