Gorilla Vs 100 Men features a scenario in which a single primate fights a crowd of humans in a third-person, 3D environment. The gameplay is a brawl based on direct physical contact, with the player's character punching and smashing enemies that constantly attack. Every push or collision is subject to ragdoll physics, creating unpredictable situations during the constant fight. There are no waves of enemies or breaks between their appearance; the action is a continuous test of endurance.